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[2] Gusella, J. F., McNeil, S., Persichetti, F., Srinidhi, J., Novelletto, A., Bird,E., Faber, P., Vonsattel, J. P., Myers, R. H. and MacDonald, M. E. (1996).Huntington’s disease. Cold Spring Harbor Symposia on Quantitative Biology 61: 615-26.
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[3] H untington, G. (1872). On chorea. Medical and Surgical Reporter 26
:317-21.
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[4] W exler, N. (1992). Clairvoyance and caution: repercussions from the Human Genome Project. In The code of codes (ed. D. Kevles and L.Hood), pp. 211-43. Harvard University Press.
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[5] H untington’s Disease Collaborative Research Group (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 72: 971-83.
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[6] Goldberg, Y. P. et al. (1996). Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.Nature Genetics 13: 442-9; DiFiglia, M., Sapp, E., Chase, K. O., Davies,S. W., Bates, G. P., Vonsattel, J. P. and Aronin, N. (1997). Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277: 1990-93.
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[7] Kakizuka, A. (1998). Protein precipitation: a common etiology in neurodegenerative disorders? Trends in genetics 14: 398-402.
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[8] B at, O., Kimmel, M. and Axelrod, D. E. (1997). Computer simulation of expansions of DNA triplet repeats in the fragile-X syndrome and Huntington’s disease. Journal of Theoretical Biology 188: 53-67.
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[9] S chweitzer, J. K. and Livingston, D. M. (1997). Destabilisation of CAG trinucleotide repeat tracts by mismatch repair mutations in yeast.Human Molecular Genetics 6: 349-55.
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[10] M angiarini, L. (1997). Instability of highly expanded CAG repeats in mice transgenic for the Huntington’s disease mutation. Nature Genetics 15: 197-200; Bates, G. P., Mangiarini, L., Mahal, A. and Davies, S. W. (1997). Transgenic models of Huntington’s disease.Human Molecular Genetics 6: 1633-7.
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[11] C hong, S. S. et al. (1997). Contribution of DNA sequence and CAG size to mutation frequencies of intermediate alleles for Huntington’s disease: evidence from single sperm analyses. Human Molecular Genetics 6: 301-10.
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[12] Wexler, N. S. (1992). The Tiresias complex: Huntington’s disease as a paradigm of testing for late-onset disorders. FASEB Journal 6: 2820-25.
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[13] Wexler, A. (1995). Mapping fate. University of California Press, Los Angeles.
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5号染色体
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在搜寻基因方面，最好的一本书是威廉·库克森的《基因猎人：基因组丛林中的冒险》（奥鲁姆出版社，1994）。库克森的这本书是我搜寻哮喘基因的主要信息来源之一。
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[1] H amilton, G. (1998). Let them eat dirt. New Scientist, 18 July 1998: 26-31; Rook, G. A. W. and Stanford, J. L. (1998). Give us this day our daily germs. Immunology Today 19: 113-16.
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[2] C ookson, W. (1994). The gene hunters: adventures in the genome jungle.Aurum Press, London.
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[3] M arsh, D. G. et al. (1994). Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin-E concentrations.Science 264: 1152-6.
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[4] M artinez, F. D. et al. (1997). Association between genetic polymorphism of the beta-2-adrenoceptor and response to albuterol in children with or without a history of wheezing. Journal of Clinical Investigation 100
:3184-8.
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6号染色体
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罗莎琳德·阿登（Rosalind Arden）在即将出版的书中将讲述罗伯特·普洛明寻找影响智商的基因的故事。普洛明关于行为遗传学的教科书《行为遗传学》（第三版，1997），可读性强，堪称该领域的入门必备书。斯蒂芬·杰伊·古尔德的《人类的误测》（诺顿出版社，1981）很好地讲述了优生学和智商的早期历史。而劳伦斯·赖特（Lawrence Wright）的《双胞胎：基因、环境和身份的奥秘》（魏登菲尔德·尼科尔森出版社，1997）一书，读后令人颇有畅快之感。
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[1] C horney, M. J., Chorney, K., Seese, N., Owen, M. J., Daniels, J.,McGuffin, P., Thompson, L. A., Detterman, D. K., Benbow, C, Lubinski,D., Eley, T. and Plomin, R. (1998). A quantitative trait locus associated with cognitive ability in children. Psychological Science 9: 1-8.
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[2] Galton, F. (1883). Inquiries into human faculty. Macmillan, London.
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[3] Goddard, H. H. (1920), quoted in Gould, S. J. (1981). The mismeasure of man. Norton, New York.
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[4] N eisser, U. et al. (1996). Intelligence: knowns and unknowns. American Psychologist 51: 77-101.
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[5] P hilpott, M. (1996). Genetic determinism. In Tarn, H. (ed.), Punishment,excuses and moral development. Avebury, Aldershot.
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