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第十八章
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I 肽基转移酶中心的精确结构和催化原理参见：Yonath, A.(2002). High-resolution structures of large ribosomal sub units from mesophilic eubacteria and halophilic archaea at various functional States.Current protein and peptide science, 3(1): 67‐78; Agmon, I.; Bashan, A.; Zarivach, R.; Yonath, A.(2005). Symmetry at the active site of the ribosome: struc tural and functional implications.Biological chemistry, 386(9): 833‐844。
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II 肽基转移酶中心与转运RNA的相似性参见：Agmon, I.(2009). The dimeric proto-ribosome: Structural details and possi ble implications on the origin of life.International journal of molecular sciences, 10(7): 2921‐2934。
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III 原始蛋白质翻译系统自发组织假说参见：Agmon, I.(2018). Hypothesis: spontaneous advent of the prebiotic translation system via the accumulation of L-shaped RNA elements.International journal of molecular sciences, 19(12): 4021。
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IV RNA自组织通用模块参见：Jaeger, L.; Chworos, A.(2006). The architectonics of programmable RNA and DNA nano structures.Current opinion in structural biology, 16(4)
:531‐543。
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V 阿格蒙的L形模块自发组织成蛋白质翻译系统假说参见：Agmon, I.(2009). The dimeric proto-ribosome: Structural details and possible implications on the origin of life.International journal of molecular sciences, 10(7): 2921‐2934; Agmon,I.(2018). Hypothesis: spontaneous advent of the prebiotic translation system via the accumulation of L-shaped RNA elements.International journal of molecular sciences, 19(12): 4021。
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VI 转运信使RNA参见：Giudice, E.; Macé, K.; Gillet, R.(2014). Trans-translation exposed: understanding the structures and functions of tmRNA-SmpB.Frontiers in Microbiology, 5
:113。
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VII 雷纳尔德·吉莱的信使RNA起源假说参见：Macé, K.; Gillet, R.(2016). Origins of tmRNA: the missing link in the birth of protein synthesis?Nucleic Acids Research, 44(17): 8041–8051; Guyomar, C.; Gillet, R.(2019). When transfer‐messenger RNA scars reveal its ancient origins.Annals of the New York Academy of Sciences, 1447: 80-87。
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第五幕
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第十九章
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I 费托合成反应制造脂肪酸参见：McCollom, T. M.; Seewald, J. S.(2007). Abiotic synthesis of organic compounds in deep sea hydrothermal environments.Chemical Reviews, 107(2): 382–401; McCollom, T. M.; Seewald, J. S.(2006). Carbon isotope composition of organic compounds produced by abiotic synthesis under hydrothermal conditions.Earth and planetary science letters, 243(1–2): 74-84; McCollom, T.M.; Ritter, G.; Simoneit, B.R.T.(1999). Lipid Synthesis under hydrothermal conditions by Fischer-Tropsch-Type reactions.Origins of life and evolution of biospheres, 29(2): 153–166。
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II 脂肪酸与氨基酸混合物的原始细胞膜参见：Cornell, C. E.; Black, R. A.; Xue, M.; et al.(2019). Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes.Proceedings of the National Academy of Sciences, 116(35): 17239-17244。
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III 尼克·莱恩的脂肪酸与类异戊二烯混合物的原始细胞膜参见：Jordan, S.F.; Rammu, H.; Zheludev, I. N.; et al.(2019).Promotion of protocell self-assembly from mixed amphiphiles at the origin of life.Nature ecology & evolution, 3: 1705–1714。
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IV 杰克·绍斯塔克用柠檬酸稳定原始细胞膜参见：O’Flaherty, D. K.; Kamat, N. P.; Mirza, F. N.; et al.(2018). Copying of Mixed-Sequence RNA Templates inside Model Protocells.Journal of the American Chemical Society, 140(15)
:5171‐5178; Adamala, K.; Szostak, J. W.(2013). Nonenzymatic template-directed RNA synthesis inside model protocells.Science, 342(6162): 1098‐1100。
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V 杰克·绍斯塔克的原始细胞分裂实验参见：Hanczyc, M. M.; Fujikawa, S. M.; Szostak, J. W.(2003). Experimental models of primitive cellular compartments: encapsulation, growth, and division.Science, 302(5645): 618-622; Zhu, T. F.; Szostak, J. W.(2009). Coupled growth and division of model protocell membranes.Journal of the American Chemical Society, 131(15): 5705‐5713; Budin, I.; Debnath, A.; Szostak, J. W.(2012). Concentration-driven growth of model protocell membranes.Journal of the American Chemical Society, 134(51): 20812‐20819。
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VI 杰克·绍斯塔克用肽把RNA吸附在原始细胞膜上的实验参见：Kamat, N.P.; Tobé, S.; Hill, I. T.; Szostak, J. W.(2015).Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides.Angewandte chemie international edition, 54(40): 11735‐11739。
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VII 杰克·绍斯塔克发现RNA自我复制能够促进原始细胞膜扩增，参见：Chen, I. A.; Roberts, R. W.; Szostak, J. W.(2004).The emergence of competition between model protocells.Science, 305(5689)
:1474‐1476。
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VIII 杰克·绍斯塔克发现磷脂促进原始细胞膜吸收胶束，参见：Budin, I.; Szostak, J. W.(2011). Physical efects underlying the transition from primitive to modern cell membranes.Proceedings of the National Academy of Sciences, 108(13): 5249‐5254。
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IX 脂肪酸合成参考文献：Dijkstra, Albert J., R. J. Hamilton, and Wolf Hamm. “Fatty Acid Biosynthesis.” Trans Fatty Acids. Oxford: Blackwell Pub., 2008. 12. Print.
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X 古菌合成类异戊二烯细胞膜，参见：Jain, S.; Caforio, A.; Driessen, A. J.(2014). Biosynthesis of archaeal membrane ether lipids.Frontiers in microbiology, 5: 641。
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第二十章
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I 人工合成铁硫蛋白参见：Mutter, A. C.; Tyryshkin, A. M.; Campbell, I. J.; et al.(2019). De novo design of symmetric ferre doxins that shuttle electrons in vivo.Proceedings of the National Academy of Sciences, 116(29): 14557-14562。
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II 能量转换氢化酶结构参见：Schoelmerich, M. C.; Müller, V.(2019). Energy conservation by a hydrogenase-dependent che miosmotic mechanism in an ancient metabolic pathway.Proceedings of the National Academy of Sciences, 116(13): 6329-6334;Shafaat, H. S.; Rüdiger, O.; Ogata, H.; Lubitz, W.(2013). [NiFe] hydrogenases: A common active site for hydrogen metabolism under diverse conditions.Biochimica et Biophysica Acta (BBA) – Bioenergetics, 1827(8–9): 986-1002。
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III 尼克·莱恩和威廉·马丁关于原始细胞膜的能量代谢，参见：Lane, N.; Martin, W. F.(2012). The origin of membrane bioenergetics.Cell, 151(7): 1406‐1416。
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IV 能量转换氢化酶工作机制参考文献：Kurkin, S.; Meuer, J.; Koch, J.; et al.(2002). The membrane-bound [NiFe]-hy drogenase (Ech) from Methanosarcina barkeri: unusual properties of the iron–sulphur clusters.European journal of biochemistry, 269(24): 6101-6111; Forzi, L.; Koch, J.; Guss, A. M.; et al.(2005). Assignment of the [4Fe–4S] clusters of Ech hydrogenase from Methanosarcina barkeri to individual subunits via the characterization of site-directed mutants.FEBS journal, 272(18): 4741-4753。
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