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1700637640 （许　毅）

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1700637645 内科学新进展 [:1700627042]

1700637646 内科学新进展 第十二章　血浆净化疗法在内科难治性疾病中的临床应用

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1700637648 摘　要　血浆净化疗法通过体外循环分离、置换血浆，清除患者血浆中致病物质以达到治疗目的的一种血液净化治疗新方法。根据分离血浆的方法，分为离心法和膜式血浆分离法，膜式血浆分离法在临床上易于实施，临床应用日益广泛。血浆净化疗法临床适应证相当广泛，已应用于抗基底膜病及各种难治性肾小球肾炎、肾病综合征等肾脏疾病，此外还应用于系统性红斑狼疮、慢性及恶性类风湿关节炎等自身免疫性疾病和重症肌无力、格林—巴利综合征等免疫性神经系统疾病及重症肝炎、血液系统疾病、高脂血症的治疗等。目前新的研究和发展还在不断进行，以使这一技术更趋完善合理，今后将在临床上将发挥越来越重要的作用。

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1700637650 Abstract　Plasmapheresis is a new technique to clean plasma pathogens by extracorporal plasma separation and exchange. The technique originated in the development of centrifugal devices separating plasma from cells. Subsequently, membrane filtration was developed and widely used in clinic for its facility to operate. So far, plasmapheresis was applied to treat various intractable diseases described following: kidney diseases including anti-glomerular basement membrane glomerular nephritis, intractable glomerular nephritis, nephritic syndrome et al., autoimmune diseases including systemic lupus erythematosus, chronic and malignant rheumatoid arthritis et al., neurological diseases including myasthenia gravis, acute Guillain-Barre syndrome et al., severe hepatisis as well as hyperlipidemia. Currently, plasmapheresis is a rapidly developing blood purification technique, and it would be a reasonable and perfect therapeutic way to play important role in clinical practices.

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1700637652 血浆净化疗法（plasmapurification）是一种通过体外循环分离、置换血浆，清除患者血浆中的一些致病物质，以达到治疗目的的一种血液净化新方法。根据分离血浆的方法，主要分为离心法和膜分离法两大类，特别是膜式血浆分离法的开发应用使治疗性血浆净化技术变得更加安全，并在临床治疗上易于实施，从而使得该技术得到迅速普及。

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