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可根据不同的疾病选择离心分离法、双重滤过法（DFPP法）、结合法（combination method)、免疫吸附法（ITR, IPH)。
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4．血浆净化疗法的效果
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表12-10总结了针对寻常性天疱疮（pemphigus vulgaris, PV）的血浆净化疗法的效果。目前日本对于治疗效果的判断标准依据为：①天疱疮抗体效价的变动；②临床症状的改善等；③肾上腺皮质激素的减量情况；④缓解期间长短；⑤副作用。表12-10显示了根据上述标准判断，在实施离心分离法、双重滤过法（DFPP法）、结合法（combination method)、免疫吸附法（ITR, IPH）后的治疗效果比较。除了IPH法以外，通过其他方法治疗后均观察到天疱疮抗体效价的减少，80％以上病例的临床症状得到改善。另外，对缓解的病例，在其后长期的观察中也未见复发的情况。同时，各种治疗方法实施后均未发现严重的副作用。
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表12-10 寻常性天疱疮的血浆净化治疗效果
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【思考题】
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1．简述血浆净化疗法治疗难治性疾病的原理。
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2．血浆置换的原理、分类，并简述应用范围。
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参考文献
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（陈江华 黄洪锋）
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内科学新进展 [:1700627043]
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内科学新进展 第十三章 分子生物学在内科领域中的应用
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摘 要 随着生命科学各个学科的发展和相互促进，医学分子生物学得以惊人的速度向临床医学的各个领域渗透，并在研究和认识人体的生理和病理现象、揭示疾病的病因及发病机理等方面发挥着越来越重要的作用。目前，分子生物学诊断技术在临床检测方面日益显现出举足轻重的地位。而基因治疗方式的完善与不断深入研究，使其在内科领域中逐步展示出广阔的应用前景。本文就分子生物学手段在临床内科疾病诊治领域的研究与应用作一简要介绍。
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Abstract With the development and mutual enhancement of the different sub-disciplines in Life Science, the Medical Molecular Biology got a high speed of progress in the territories of Clinical Medicine. It gradually shows an important role in the understanding of the physiological and pathological phenomena, as well as in the demonstration of the etiology and pathogenesis of different diseases. Nowadays, in the practice of daily clinical detection in many hospitals, the development of Molecular Diagnosis urges a high ratio of positive measurement. Meanwhile, the progress of Genetic Therapy shows an extensive prospect in the therapy application of hereditary diseases. This article will give a brief introduction on the study and application of Medical Molecular Biology in Clinical Internal Medicine.
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