1700642684
1700642685
[7]FRIEDMAN J M, LEIBEL R L, SIEGEL D S, et al.Molecular mapping of the mouse ob mutation[J].Genomics,1991,11(4):1054-1062.
1700642686
1700642687
[8]ZHANG Y, et al.Positional cloning of the mouse obese gene and its human homologue[J].Nature,1994,372(6505):425-432.
1700642688
1700642689
[9]TARTAGLIA L A, et al.Identification and expression cloning of a leptin receptor, OB-R[J].Cell,1995,83(7):1263-1271.
1700642690
1700642691
[10]FRIEDMAN J M, HALAAS J L.Leptin and the regulation of body weight in mammals[J].Nature,1998,395(6704):763-770.
1700642692
1700642693
[11]COLEMAN D L.A historical perspective on leptin[J].Nature,2010,Medicine 16(10):1097-1099.[12]LOFFREDO FRANCESCO S, et al.Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy[J].Cell,2013,153(4):828-839.
1700642694
1700642695
[13]FRIEDMAN J.20 YEARS OF LEPTIN:Leptin at 20:an overview[J].Journal of Endocrinology,2014,223(1):T1-T8.
1700642696
1700642697
[14]KATSIMPARDI L, et al.Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors[J].Science,2014,344(6184):630-634.
1700642698
1700642699
[15]LAVIANO A.Young blood[J].New England Journal of Medicine,2014,371(6):573-575.
1700642700
1700642701
[16]KAISER J.‘Rejuvenating’protein doubted[J].Science,2015,348(6237):849-849.
1700642702
1700642703
第二章
1700642704
1700642705
[17]COHEN S N, CHANG A C Y, BOYER H W, et al.Construction of biologically functional bacterial plasmids in vitro[J].Proceedings of the National Academy of Sciences of the United States of America,1973,70(11):3240-3244.
1700642706
1700642707
[18]HOGAN S, et al.Studies on the antiobesity activity of tetrahydrolipstatin, a potent and selective inhibitor of pancreatic lipase[J].International Journal of Obesity,1987,11(Suppl 3):35-42.
1700642708
1700642709
[19]WEINTRAUB M.Long-term weight control study:conclusions[J].Clinical Pharmacology&Therapeutics,1992,51(5):642-646.
1700642710
1700642711
[20]BRAY G A.Amphetamine:thejanus of treatment for obesity[J].Obesity Research,1994,2(3):282-285.
1700642712
1700642713
[21]CAMPFIELD L A, SMITH F J, GUISEZ Y, et al.Recombinant mouse OB protein:evidence for a peripheral signal linking adiposity and central neural networks[J].Science,1995,269(5223):546-549.
1700642714
1700642715
[22]HALAAS J L, et al.Weight-reducing effects of the plasma protein encoded by the obese gene[J].Science,1995,269(5223):543-546.
1700642716
1700642717
[23]PELLEYMOUNTER M A, et al.Effects of the obese gene product on body weight regulation in ob/ob mice[J].Science,1995,269(5223):540-543.
1700642718
1700642719
[24]STEPHENS T W, et al.The role of neuropeptide Y in the antiobesity action of the obese gene product[J].Nature,1995,377(6549):530-532.
1700642720
1700642721
[25]MONTAGUE C T, e t a l.Congenital leptin deficiency is associated with severe early-onset obesity in humans[J].Nature,1997,387(6636):903-908.
1700642722
1700642723
[26]FAROOQI I S, et al.Beneficial effects of leptin on obesity, T cellhyporesponsiveness, and neuroend ocrine/metabolic dysfunction of human congenitalleptin deficiency[J].The Journal of Clinical Investigation,2002,110(8):1093-1103.
1700642724
1700642725
[27]ORAL E A, et al.Leptin-replacement therapy for lipodystrophy[J].New England Journal of Medicine,2002,346(8):570-578.
1700642726
1700642727
[28]VAN MARKEN LICHTENBELT W D, et al.Cold-activated brown adipose tissue in healthy men[J].New England Journal of Medicine,2009,360(15):1500-1508.
1700642728
1700642729
[29]HILL J O, WYATT H R, PETERS J C.Energy balance and obesity[J].Circulation,2012,126(1):126-132.
1700642730
1700642731
[30]COHEN S N.DNA cloning:a personal view after 40 years[J].Proceedings of the National Academy of Sciences,2013,110(39):15521-15529.
1700642732
1700642733
[31]OGDEN C L, CARROLL M D, KIT B K, et al.Prevalence of childhood and adult obesity in the united states,2011-2012[J].JAMA,2014,311(8):806-814.
[
上一页 ]
[ :1.700642684e+09 ]
[
下一页 ]