打字猴:1.700649276e+09
1700649276
1700649277 A Song in the Night:A Memoir of Resilience by Bob Massie(Doubleday,2012).
1700649278
1700649279 布鲁斯·沃克与鲍勃·马西之间的关联,以及前者对于这些非凡控制者世代的研究进程,其细节来自个人访谈。其他细节以及“我那时一定大声地惊叹了一声”这句话,摘录自:“Secrets of the HIV controllers,” Scientific American 307(2012).
1700649280
1700649281 关于囊肿性纤维化的基因治疗,详见:“Cystic fibrosis transmembrane conductance regulator protein repair as a therapeutic strategy in cystic fibrosis,” Current Opinion in Pulmonary Medicine 16(2010).
1700649282
1700649283 关于帕金森病的基因治疗,详见:“Safety and tolerability of gene therapy with an adeno-associated virus(AAV)borne GAD gene for Parkinson’s disease:an open label,phase I trial,” Lancet 369(2007).
1700649284
1700649285 关于乙型地中海贫血的基因治疗,详见:“Beta-thalassemia treatment succeeds,with a caveat,” Science 326(2009).
1700649286
1700649287 关于遗传性失明的基因治疗,详见:Maguire AM,High KA,Auricchio A,Wright JF,Pierce EA,Testa F,Mingozzi F,Bennicelli JL,Ying GS,Rossi S,et al.,“Age-dependent effects of RPE65 gene therapy for Leber’s congenital amaurosis:a phase 1 dose-escalation trial,” Lancet 374(9701):1597-605;2009.
1700649288
1700649289 关于杰西·格尔辛格于1999年在接受基因治疗后死亡及其对研究引起的冲击,详见:“Gene therapy death prompts review of adenovirus vector,” Science 286(1999).
1700649290
1700649291 关于流行病学及HIV控制者的描述,详见:“Prevalence and comparative characteristics of long-term nonprogressors and HIV controller patients in the French Hospital Database on HIV,” AIDS 23(2009).
1700649292
1700649293 关于淋巴细胞组织大量表现CCR5的现象,详见:“Expression of the chemokine receptors CCR4,CCR5,and CXCR3 by human tissue-infiltrating lymphocytes,” American Journal of Pathology 160(2002).
1700649294
1700649295 关于肠道在HIV急性感染期的重要性的讨论,详见:“Immunopathogenesis of acute AIDS virus infection,” Current Opinion in Immunology 18(2006).
1700649296
1700649297 关于人类白细胞抗原分型与HIV的概论,详见:“HIV and HLA class I:an evolving relationship,” Immunity 37(2012).
1700649298
1700649299 关于HIV控制者的身上常可发现HLA对偶基因B*27和B*57,详见:“HLA alleles associated with delayed progression to AIDS contribute strongly to the initial CD8+ T-cell response against HIV-1,” PLoS Medicine 3(2006).
1700649300
1700649301 关于猴子版的HIV非凡控制,Mamu-A*01对偶基因的出现能够保护灵长类免于SIV的感染,详见:“Mamu-A*01 allele-mediated attenuation of disease progression in simian-human immunodeficiency virus infection,” Journal of Virology 76(2002).
1700649302
1700649303 关于控制着HIV,且位于HLA-B基因沟中的特定氨基酸,详见:“The major genetic determinants of HIV-1 control affect HLA class I peptide presentation,” Science 330(2010).
1700649304
1700649305 关于HLA-B*57与银屑病之关联的探讨,详见:“HLA-B57 is significantly associated with psoriasis in Northeast Romania,” Roumanian Archives of Microbiology and Immunology 61(2002).
1700649306
1700649307 12 躲藏起来的疗法
1700649308
1700649309 关于医学院毕业生担任家庭医生的比例,详见:“Entry of US medical school graduates into family medicine residencies,” Family Medicine 44(2012).
1700649310
1700649311 首篇探讨羟基脲临床表现的报告:“Hydroxyurea. a new type of potential antitumor agent,” Journal of Medicinal Chemistry 6(1963).
1700649312
1700649313 关于美国食品药品管理局所核准的羟基脲的基本作用机制和治疗疾病,详载于在市面贩卖的爱治,也就是羟基脲胶囊的商品说明上。此为美国药典出版,百时美施贵宝出品。
1700649314
1700649315 13 第二次确诊
1700649316
1700649317 在美国,2006—2010年,确诊了急性骨髓性白血病(AML)的成年患者,其5年存活率仅有25%。而复发的患者其5年存活率仅有11%。此报告由国家癌症研究所公布于:SEER cancer statistics review,1975-2010 (2012).
1700649318
1700649319 关于AML如何侵入组织,及其在临床上造成的效果的一篇回顾:“Acute myeloid leukaemia in adults,” Lancet 381(2013).
1700649320
1700649321 关于AML中可能发生的免疫抑制现象的讨论,详见:“Commentary:does immune suppression increase risk of developing acute myeloid leukemia?” Leukemia 26(2012).
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1700649323 关于造血干细胞的更多细节,详见:Hematopoietic Stem Cell Biology ,edited by Motonari Kondo(Humana Press,2010).
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1700649325 关于异体干细胞的移植,详见:“Allogeneic hematopoietic cell transplantation for acute myeloid leukemia when a matched related donor is not available,” Hematology 2008(2008).
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