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西地那非在1998年被批准上市，商品名为Viagra。第一季度在美国市场即发出290万个处方。
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因肺动脉高压（可导致右心衰竭）也可以用PDE5抑制剂来治疗。FDA于2005年批准了西地那非治疗肺动物高压的适应证。但商品名为Revatio。
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2008年西地那非销量达到19亿美元。2013年，辉瑞公司宣布将在网上向患者直接出售本品。
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参考文献
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[2]FERREIRA S H. A bradykinin-potentiating factor (bpf) present in the venom of bothrops jararaca[J]. British Journal of Pharmacology, 1965,24: 163-169.
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[3]BYERS L D, WOLFENDEN R. Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A[J]. Biochemistry, 1973, 12
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[4]SACHS G, CHANG H H, RABON E, et al. A nonelectrogenic H+ pump in plasma membranes of hog stomach[J]. Journal of Biological Chemistry, 1976, 251(23)
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[5]LINDBERG P, BRÄNDSTRÖM A, et al. Omeprazole: the first proton pump inhibitor[J]. Medicinal Research Reviews, 1990, 10(1): 1-54.
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[6]ENDO A, KURODA M, TSUYITA Y. ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium[J]. Journal of Antibiotics, 1976, 29
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[7]ALBERTS A W, CHEN J, et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent[J]. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 1980, 77(7)
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[8]SOHDA T, MIZUNO K, et al. Studies on antidiabetic agents. Ⅱ. Synthesis of 5-[4-(1-methylcyclohexylmethoxy)-benzyl]thiazolidine-2,4-dione(ADD-3878) and its derivatives[J]. Chemical and Pharmaceutical Bulletin, 1982, 30: 3580-3600.
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[9]ENG J, KLEINMAN W A, et al. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom.Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas[J]. Journal of Biological Chemistry, 1992, 267(11)
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极简新药发现史 第8章现代生物药的发现
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随着生物技术的发展，除了胰岛素、疫苗外，越来越多的生物因子、生物药品被应用到临床当中，并不断扩大市场份额，已经达到与传统化学药品竞争的地步。
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肾衰竭与促红细胞生成素
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