打字猴:1.70055592e+09
1700555920 西地那非在1998年被批准上市,商品名为Viagra。第一季度在美国市场即发出290万个处方。
1700555921
1700555922 因肺动脉高压(可导致右心衰竭)也可以用PDE5抑制剂来治疗。FDA于2005年批准了西地那非治疗肺动物高压的适应证。但商品名为Revatio。
1700555923
1700555924 2008年西地那非销量达到19亿美元。2013年,辉瑞公司宣布将在网上向患者直接出售本品。
1700555925
1700555926 极简新药发现史 [:1700552796]
1700555927 参考文献
1700555928
1700555929 [1]GRÜN G, FLECKENSTEIN A. Electromechanical uncoupling of vascular smooth muscle as the basic principle of coronary dilatation by 4-(2′-nitrophenyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester (BAY a 1040, Nifedipine). 1. The significance of Ca++ions for the bioelectrical and mechanical activity of smooth muscle[J].Arzneimittel-forschung, 1972, 22(2):334-344.
1700555930
1700555931 [2]FERREIRA S H. A bradykinin-potentiating factor (bpf) present in the venom of bothrops jararaca[J]. British Journal of Pharmacology, 1965,24: 163-169.
1700555932
1700555933 [3]BYERS L D, WOLFENDEN R. Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A[J]. Biochemistry, 1973, 12:2070-2078.
1700555934
1700555935 [4]SACHS G, CHANG H H, RABON E, et al. A nonelectrogenic H+ pump in plasma membranes of hog stomach[J]. Journal of Biological Chemistry, 1976, 251(23):7690-7698.
1700555936
1700555937 [5]LINDBERG P, BRÄNDSTRÖM A, et al. Omeprazole: the first proton pump inhibitor[J]. Medicinal Research Reviews, 1990, 10(1): 1-54.
1700555938
1700555939 [6]ENDO A, KURODA M, TSUYITA Y. ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium[J]. Journal of Antibiotics, 1976, 29:1346-1348.
1700555940
1700555941 [7]ALBERTS A W, CHEN J, et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent[J]. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 1980, 77(7):3957-3961.
1700555942
1700555943 [8]SOHDA T, MIZUNO K, et al. Studies on antidiabetic agents. Ⅱ. Synthesis of 5-[4-(1-methylcyclohexylmethoxy)-benzyl]thiazolidine-2,4-dione(ADD-3878) and its derivatives[J]. Chemical and Pharmaceutical Bulletin, 1982, 30: 3580-3600.
1700555944
1700555945 [9]ENG J, KLEINMAN W A, et al. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom.Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas[J]. Journal of Biological Chemistry, 1992, 267(11):7402-7405.
1700555946
1700555947 [10]KILPATRICK G J, JONES B J, TYERS M B. Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding[J].Nature, 1987, 330(6150):746-748.
1700555948
1700555949 [11]KRAMER M S, CUTLER N, et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors[J]. Science,1998, 281 (5383):1640-1645.
1700555950
1700555951 [12]MEIER R, GROSS F, TRIPOD J. Ritalin, a new synthetic compound with specific analeptic components[J]. Klinische Wochenschrift, 1954,32 (19-20): 445-450.
1700555952
1700555953 [13]MEHTA N B. The chemistry of bupropion[J]. The Journal of Clinical Psychiatry, 1983, 44(5Pt2):56-59.
1700555954
1700555955 [14]MEUNIER H, CARRAZ G, et al. Pharmacodynamic properties of N-dipropylacetic acid[J]. Therapie, 1963, 18:435-438.
1700555956
1700555957 [15]FLEISCH H, RUSSELL R G, BISAZ S, et al. Influence of diphosphonates on the deposition and dissolution of ccalcium phosphate in vitro and in vivo[J]. Helvetica Physiologica et Pharmacologica Acta, 1968, 26(3):345-346.
1700555958
1700555959
1700555960
1700555961
1700555962 极简新药发现史 [:1700552797]
1700555963 极简新药发现史 第8章现代生物药的发现
1700555964
1700555965 随着生物技术的发展,除了胰岛素、疫苗外,越来越多的生物因子、生物药品被应用到临床当中,并不断扩大市场份额,已经达到与传统化学药品竞争的地步。
1700555966
1700555967 极简新药发现史 [:1700552798]
1700555968 肾衰竭与促红细胞生成素
1700555969
[ 上一页 ]  [ :1.70055592e+09 ]  [ 下一页 ]