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【思考题】
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1．讨论自身免疫性疾病与人类进化的关系。
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2．试述自身免疫性疾病与人类机体免疫防御功能之间的关系。
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3．试述自身免疫性疾病的发病机制与治疗策略之间的关系。
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4．试述自身免疫性疾病的生物治疗的非特异方法和特异性方法。
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参考文献
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[1] 蒋明，等主编．风湿病学．北京：科学出版社，1995.
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[2] Noel R. Rose. Symposium proceedings. J Invest Dermatol, 2004, 9(1)
:1-4.
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[3] Theofilopoulos AN. Genes and genetics of autoimmunity. KARGER, 1999.
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[4] Theofilopoulos AN. Biologic and gene therapy of autoimmune disease KARGER, 2000.
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[5] 吴东海，王国春主编．实用临床风湿病杂志．北京：中国医药科技出版社，2000.
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[6] 杨晓红，满孝勇，郑敏．调节性T细胞与过敏性皮肤病．中国麻风皮肤病杂志，2007，23(9)
:797-799.
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[7] 郑敏．提高对自身免疫性疾病的预知与预防水平．国际皮肤性病学杂志，2006，32(6)335-337.
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[8] 王庭辉、郑敏．凋亡物质清除障碍与系统性红斑狼疮．国际皮肤性病学杂志，2006，32(6)365-367.
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[9] 周建光，郑敏．HMGB1在风湿病中的作用．浙江大学学报医学版，2007，36(4)
:412-6.
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[10] 温丽虹，郑敏．自身免疫病的研究进展（综述）．国外医学·皮肤性病学分册，2005，5(31)
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[11] Browning JL. B cells move to centre stage: novel opportunities for autoimmune disease treatment. Nat Rev Drug Discover, 2006, 5
:564-579.
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[12] Harel M, Shoenfeld Y. Predicting and preventing autoimmunity, myth or reality? Ann N Y Acad Sci, 2006, 1069
:322-345.
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[13] Arbuckle, MR. et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med, 2003, 349
:1526-1533.
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[14] Scofield, RH. Autoantibodies as predictors of disease. Lancet, 2004, 363
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[15] Gelber AC, Wigley FM. Disease severity as a predictor of outcome in scleroderma. Lancet, 2002, 359
:277-279.
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[16] Kim R, Emi M, Tanabe K. Cancer immunosuppression and autoimmune disease: beyond immunosuppressive networks for tumour immunity. Immunology, 2006, 1-10.
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[17] Dejaco C, Duftner C, Grubeck B, et al. Imbalance of regulatory T cells in human autoimmune diseases. Immunology, 2006, 117
:289-300.
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（郑 敏）
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