1700642690
1700642691
[10]FRIEDMAN J M, HALAAS J L.Leptin and the regulation of body weight in mammals[J].Nature，1998，395（6704）：763-770.
1700642692
1700642693
[11]COLEMAN D L.A historical perspective on leptin[J].Nature，2010，Medicine 16（10）：1097-1099.[12]LOFFREDO FRANCESCO S, et al.Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy[J].Cell，2013，153（4）：828-839.
1700642694
1700642695
[13]FRIEDMAN J.20 YEARS OF LEPTIN：Leptin at 20：an overview[J].Journal of Endocrinology，2014，223（1）：T1-T8.
1700642696
1700642697
[14]KATSIMPARDI L, et al.Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors[J].Science，2014，344（6184）：630-634.
1700642698
1700642699
[15]LAVIANO A.Young blood[J].New England Journal of Medicine，2014，371（6）：573-575.
1700642700
1700642701
[16]KAISER J.‘Rejuvenating’protein doubted[J].Science，2015，348（6237）：849-849.
1700642702
1700642703
第二章
1700642704
1700642705
[17]COHEN S N, CHANG A C Y, BOYER H W, et al.Construction of biologically functional bacterial plasmids in vitro[J].Proceedings of the National Academy of Sciences of the United States of America，1973，70（11）：3240-3244.
1700642706
1700642707
[18]HOGAN S, et al.Studies on the antiobesity activity of tetrahydrolipstatin, a potent and selective inhibitor of pancreatic lipase[J].International Journal of Obesity，1987，11（Suppl 3）：35-42.
1700642708
1700642709
[19]WEINTRAUB M.Long-term weight control study：conclusions[J].Clinical Pharmacology&Therapeutics，1992，51（5）：642-646.
1700642710
1700642711
[20]BRAY G A.Amphetamine：thejanus of treatment for obesity[J].Obesity Research，1994，2（3）：282-285.
1700642712
1700642713
[21]CAMPFIELD L A, SMITH F J, GUISEZ Y, et al.Recombinant mouse OB protein：evidence for a peripheral signal linking adiposity and central neural networks[J].Science，1995，269（5223）：546-549.
1700642714
1700642715
[22]HALAAS J L, et al.Weight-reducing effects of the plasma protein encoded by the obese gene[J].Science，1995，269（5223）：543-546.
1700642716
1700642717
[23]PELLEYMOUNTER M A, et al.Effects of the obese gene product on body weight regulation in ob/ob mice[J].Science，1995，269（5223）：540-543.
1700642718
1700642719
[24]STEPHENS T W, et al.The role of neuropeptide Y in the antiobesity action of the obese gene product[J].Nature，1995，377（6549）：530-532.
1700642720
1700642721
[25]MONTAGUE C T, e t a l.Congenital leptin deficiency is associated with severe early-onset obesity in humans[J].Nature，1997，387（6636）：903-908.
1700642722
1700642723
[26]FAROOQI I S, et al.Beneficial effects of leptin on obesity, T cellhyporesponsiveness, and neuroend ocrine/metabolic dysfunction of human congenitalleptin deficiency[J].The Journal of Clinical Investigation，2002，110（8）：1093-1103.
1700642724
1700642725
[27]ORAL E A, et al.Leptin-replacement therapy for lipodystrophy[J].New England Journal of Medicine，2002，346（8）：570-578.
1700642726
1700642727
[28]VAN MARKEN LICHTENBELT W D, et al.Cold-activated brown adipose tissue in healthy men[J].New England Journal of Medicine，2009，360（15）：1500-1508.
1700642728
1700642729
[29]HILL J O, WYATT H R, PETERS J C.Energy balance and obesity[J].Circulation，2012，126（1）：126-132.
1700642730
1700642731
[30]COHEN S N.DNA cloning：a personal view after 40 years[J].Proceedings of the National Academy of Sciences，2013，110（39）：15521-15529.
1700642732
1700642733
[31]OGDEN C L, CARROLL M D, KIT B K, et al.Prevalence of childhood and adult obesity in the united states，2011-2012[J].JAMA，2014，311（8）：806-814.
1700642734
1700642735
[32]BURKE L K, HEISLER L K.5-hydroxytryptamine medications for the treatment of obesity[J].Journal of Neuroendocrinology，2015，27（6）：389-398.
1700642736
1700642737
[33]CYPESS AARON M, et al.Activation of human brown adiposetissue by aβ3-adrenergic receptor agonist[J].Cell Metabolism，2015，21（1）：33-38.
1700642738
1700642739
[34]KAHAN S, ZVENYACH T.Obesity as a disease：current policies and implications for the future[J].Current Obesity Reports，2016，5（2）：291-297.
[
上一页 ]
[ :1.70064269e+09 ]
[
下一页 ]