1700642740
1700642741
第三章
1700642742
1700642743
[35]BLOCH K.The biological synthesis of cholesterol[J].Science，1965，150（3692）：19-28.
1700642744
1700642745
[36]BROWN M S, DANA S E, GOLDSTEIN J L.Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins[J].Proceedings of the National Academy of Sciences，1973，70（7）：2162-2166.
1700642746
1700642747
[37]GOLDSTEIN J L, BROWN M S.Familial hypercholesterolemia：identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol[J].Proceedings of the National Academy of Sciences，1973，70（10）：2804-2808.
1700642748
1700642749
[38]BROWN M S, GOLDSTEIN J L.Familial hypercholesterolemia：Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity[J].Proceedings of the National Academy of Sciences，1974，71（3）：788-792.
1700642750
1700642751
[39]ENDO A, KURODA M, TANZAWA K.Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity[J].FEBS Letters，1976，72（2）：323-326.
1700642752
1700642753
[40]ENDO A, KURODA M, TSUJITA Y.ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium[J].J Antibiot（Tokyo），1976，29（12）：1346-1348.
1700642754
1700642755
[41]GOLDSTEIN L J, BROWN S M.The low-density lipoprotein pathway and its relation to atherosclerosis[J].Annual Review of Biochemistry，1977，46（1）：897-930.
1700642756
1700642757
[42]BROWN M S, FAUST J R, GOLDSTEIN J L, et al.Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity inhuman fibroblasts incubated with compactin（ML-236B），a competitive inhibitor of the reductase[J].Journal of Biological Chemistry，1978，253（4）：1121-1128.
1700642758
1700642759
[43]HOBBS H H, RUSSELL D W, BROWN M S, et al.The LDL receptor locus in familial hypercholesterolemia：mutational analysis of a membrane protein[J].Annual Review of Genetics，1990，24（1）：133-170.
1700642760
1700642761
[44]ABIFADEL M, et al.Mutations in PCSK9 cause autosomal dominant hyperchole sterolemia[J].Nature Genetics，2003，34（2）：154-156.
1700642762
1700642763
[45]MAXWELL K N, BRESLOW J L.Adenoviral-mediated expression of Pcsk 9 in mice results in a low-density lipoprotein receptor knockout phenotype[J].Proceedings of the National Academy of Sciences of the United States of America，2004，101（18）：7100-7105.
1700642764
1700642765
[46]COHEN J, et al.Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9[J].Nature Genetics，2005，37（2）：161-165.
1700642766
1700642767
[47]FOX K A, STEG P, EAGLE K A, et al.Decline in rates of death and heart failure in acute coronarysyndromes，1999-2006[J].JAMA，2007，297（17）：1892-1900.
1700642768
1700642769
[48]STOSSEL T P.The Discovery of Statins[J].Cell，2008，134（6）：903-905.
1700642770
1700642771
[49]SCHEKMAN R.Discovery of the cellular and molecular basis of cholesterol control[J].Proceedings of the National Academy of Sciences，2013，110（37）：14833-14836.
1700642772
1700642773
[50]AJUFO E, RADER D J.Recent advances in the pharmacological management of hypercholes-terolaemia[J].The Lancet Diabetes&Endocrinology，2016，4（5）：436-446.
1700642774
1700642775
第四章
1700642776
1700642777
[51]OPIE E L.Pathological changes affecting the islands of Langerhans of the pancreas[J].Journal of the Boston Society of Medical Sciences，1900，4（10）：251-260.
1700642778
1700642779
[52]SANGER F, TUPPY H.The amino-acid sequence in the pheny-lalanyl chain of insulin.1.The identi-fication of lower peptides from partial hydrolysates[J].Biochemical Journal，1951，49（4）：463-481.
1700642780
1700642781
[53]SANGER F, TUPPY H.The amino-acid sequence in thephenylalanyl chain of insulin.2.The investigation of peptides from enzymic hydrolysates[J].Biochemical Journal，1951，49（4）：481-490.
1700642782
1700642783
[54]SANGER F, THOMPSON E O P.The amino-acid sequence in the glycyl chain of insulin.1.The identification of lower peptides from partial hydrolysates[J].Biochemical Journal，1953，53（3）：353-366.
1700642784
1700642785
[55]SANGER F, THOMPSON E O P.The amino-acid sequence in the glycyl chain of insulin.2.The investigation of peptides from enzymic hydrolysates[J].Biochemical Journal，1953，53（3）：366-374.
1700642786
1700642787
[56]ROSENFELD L.Insulin：discovery and controversy[J].Clinical Chemistry，2002，48（12）：2270-2288.
1700642788
1700642789
[57]KATHRYN M K, GREG R.A history of diabetes：from antiquity to discovering insulin[J].British Journal of Nursing，2003，12（18）：1091-1095.
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