打字猴:1.70064936e+09
1700649360
1700649361 关于线粒体、抗逆转录病毒疗法与脂肪萎缩的关联,详见:“Mitochondrial RNA and DNA alterations in HIV lipoatrophy are linked to antiretroviral therapy and not to HIV infection,” Antiviral Therapy 13(2008).
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1700649363 17 抓住时机
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1700649365 所有引述与利西耶维兹博士的相关背景信息,皆来自个人访谈。
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1700649367 关于信使RNA如何进行转译,详见:The Cell:A Molecular Approach ,2nd edition,by Geoffrey Cooper(Sinauer Associates,2000).
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1700649369 由利西耶维兹开创的基因疗法,可详见她的论文:“Gene therapy approaches to HIV infection,” American Journal of Pharmacogenomics 2(2002).
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1700649371 关于利西耶维兹与洛里的研究机构的更多信息,详见RIGHT网站:http://www.rightinstitute.net.
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1700649373 18 移植手术
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1700649375 一篇关于哪位AML患者应当进行骨髓干细胞移植,以及原因为何的回顾:“Who should be transplanted for AML?” Leukemia 15(2001).
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1700649377 关于AML患者在二次移植后的低存活率数据,详见:“Prognosis of patients with a second relapse of acute myeloid leukemia,” Leukemia 14(2000). 关于AML复发的成年人患者的5年存活率仅有11%,详见:“Prognostic index for adult patients with acute myeloid leukemia in first relapse,” American Society of Clinical Oncology 23(2005).
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1700649379 关于调理疗程如何抑制AML移植患者的免疫系统,详见:“Myeloablative conditioning regimens for AML allografts:30 years later,” Bone Marrow Transplantation 32(2003).
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1700649381 19 “我们可能已经消灭HIV”
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1700649383 关于临床医师如何应用的比例,详见:“CD4 percentage,CD4 number,and CD4:CD8 ratio in HIV infection:which to choose and how to use,” Journal of Acquired Immune Deficiency Syndromes 2(1989).
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1700649385 西里西亚诺极具影响力的论文:“Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy,” Science 278(1997).
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1700649387 关于血液中静止T细胞所占的比例及其与HIV的关联,详见:“Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells,” Nature 435(2005).
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1700649389 关于淋巴结为HIV最适切的目标,详见:“Lymph node pathology of acquired immunodeficiency syndrome(AIDS),” Annals of Clinical and Laboratory Science 20(1990).
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1700649391 福克斯的论文使他参与了两位柏林病人的治疗:“HIV in infected lymph nodes,” Nature 370(1994).
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1700649393 关于淋巴结结构的破坏,详见:“Human immunodeficiency virus pathogenesis:insights from studies of lymphoid cells and tissues,” Clinical Infectious Disease 33(2001).
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1700649395 自1996年起,沃克发表了数篇具影响力的论文,包括:“Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor,” Journal of Infectious Diseases 173(1996);“T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones:analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant,” Journal of Experimental Medicine 183(1996);“Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection,” AIDS Research and Human Retroviruses 12(1996);“Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load,” Journal of Immunology 156(1996);“Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes,” Journal of Virology 70(1996).
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1700649397 关于HIV和干扰素-γ在ELISPOT中的交互作用,详见:“The role of IFN-[gamma] Elispot assay in HIV vaccine research,” Nature 4(2009).
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1700649399 关于在HIV中使用ELISPOT的问题的争论,详见:“The role of IFN- Elispot assay in HIV research,” Nature Protocols 4(2009).
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1700649401 20 无法振奋人心的康复
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1700649403 德国国内生产总值(GDP)回馈至社会福利的比例与美国相比较的数据,援引自:“What the European and American welfare states have in common and where they differ:facts and fiction in comparisons of the European Social Model and the United States,” Journal of European Social Policy 20(2010).
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1700649405 2008年,逆转录病毒和机会性感染大会(CROI)上公布的抗病毒药物:新特兹(Selzentry),药名马拉维若(maraviroc),其多国多中心随机双盲临床试验(MOTIVATE)的试验结果,详见:“Efficacy and safety of maraviroc plus optimized background therapy in treatment-experienced patients infected with CCR5-tropic HIV-1:48-week combined analysis of the MOTIVATE studies,” Abstract #792,15th Conference on Retroviruses and Opportunisitic Infections,Boston,MA(2008).
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1700649407 21 临床试验
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1700649409 沃克针对HIV急性感染期免疫反应的早期论文:“Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia,” Science 278(1997).
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