打字猴:1.70064951e+09
1700649510
1700649511 2011年,米利曼医学指数评估了朱恩团队在自体移植上,给予CCR5锌指核酸的花费,为363800美元。因此这也使得自体移植的花费,较终身抗病毒疗程的花费节省了将近30万美元。详见:http://publications. milliman.com/research/health-rr/pdfs/2011-us-organ-tissue. pdf.
1700649512
1700649513 26 有个孩子被治愈了,那又如何
1700649514
1700649515 一名染上HIV的儿童被治愈的报道,详见:“Functional HIV cure after very early ART of an infected infant,” Abstract #48LB,20th Conference on Retroviruses and Opportunistic Infections,Atlanta,GA(2013).
1700649516
1700649517 关于布卢和瓦格纳的谈话内容,详见:“Revolutionary treatment begins,” University of Minnestota News (April 24,2013).
1700649518
1700649519 布朗打给布卢的电话内容,详见:“Babies could be key to HIV cure,” Washington Blade (Aplril 26,2013).
1700649520
1700649521 关于马戈利斯的背景信息,引述自个人访谈。
1700649522
1700649523 关于组蛋白去乙酰酶抑制剂(HDACi)在癌症治疗上的历史,与伏立诺他作为第一种由FDA核准的药剂等,详见:“Histone deacetylase(HDAC)inhibitors in recent clinical trials for cancer therapy,” Clinical Epigenetics 1(Dec 2010).
1700649524
1700649525 马戈利斯对HDACi的一种——丙戊酸进行的调查,详见:“Coaxing HIV-1 from resting CD4 T cells:histone deacetylase inhibition allows latent viral expression,” AIDS 18(May 21,2004),and “Depletion of latent HIV-1 infection in vivo:a proof-of-concept study,” Lancet 366(Aug 13,2005).
1700649526
1700649527 马戈利斯测试伏立诺他的数据,详见:“Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid,” AIDS Research and Human Retroviruses 25(Feb 2009).
1700649528
1700649529 马戈利斯撰写了一篇关于HDACi的精彩文献回顾,详见:“Histone deacetylase inhibitors HIV latency,” Current Opinion in HIV and AIDS 6(2011).
1700649530
1700649531 马戈利斯为大众所做的演讲内容,详见:“Administration of vorinostat disrupts HIV-1 latency in patients on ART,” Abstract #157LB,19th Conference on Retroviruses and Opportunistic Infections,Seattle,WA(2012).
1700649532
1700649533 莱温将其对伏立诺他的试验数据与分析结果,分享于:“HIV latency and eradication:clinical perspectives,” Abstract #106,19th Conference on Retroviruses and Opportunistic Infections,Seattle,WA(2012).
1700649534
1700649535 “这是有史以来,我们首度证明有方法可以专门针对潜伏病毒,这是迈向治愈HIV感染的第一步。”此话引述自莱温,收录于:“Drug helps purge hidden HIV virus,UNC study shows” from the University of North Carolina School of Medicine(March 8,2012).
1700649536
1700649537 27 锌指一弹
1700649538
1700649539 以我学位论文的研究结果为基础,坎农与我合著了一篇论文:“Zinc finger nuclease-mediated CCR5 knockout hematopoietic stem cell transplantation controls HIV-1 in vivo,” Nature Biotechnology 28(Aug 2010).
1700649540
1700649541 坎农的背景信息,援引自个人访谈。
1700649542
1700649543 加州再生医学研究所为“梦之队”提供了资助,此事详见:http://www.cirm.ca.gov/our-funding/awards/ziinc-finger-nuclease-based-stem-cell-therapy-aids.
1700649544
1700649545 坎农所说的“这方法能奏效,就像是‘根本理所当然嘛’!这是最稀松平常的事情。我那时还没心理准备,看到其他人对这些结果叹为观止”。摘录自:“Locking Out HIV,” CIRM Annual Report (2011).
1700649546
1700649547 关于亨里奇与库里茨克斯的背景信息,援引自个人访谈。
1700649548
1700649549 亨里奇第一篇关于波士顿病人的结果,详见:“Long-term reduction in peripheral blood HIV-1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation in two HIV-positive individuals,” Abstract THAA0101,XIX International AIDS Conference,Washington,DC(2012).
1700649550
1700649551 波士顿病人受到各种出版物的关注,包括:“Two More Nearing AIDS ‘Cure’ after Bone Marrow Transplants,Doctors Say,” National Public Radio,Shots health blog (July 26,2012).
1700649552
1700649553 针对控制者于疗程中断后的病毒学和免疫学研究(VISCONTI)此一队列所做的研究结果,详见:“Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI study,” PLoS Pathogens (Mar 24,2013).
1700649554
1700649555 关于巴尔的摩的背景信息,援引自个人访谈内容。
1700649556
1700649557 巴尔的摩与陈绍虞首篇关于小干扰RNA(siRNA)的论文:“Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5,” Proceedings of the National Academy of Sciences of the USA 100(Jan 7,2003).
1700649558
1700649559 “amFAR对于探究基因疗法在消灭HIV中扮演的角色,兴趣源自2009年《新英格兰医学期刊》上刊登的关于柏林一位患者的报道。”此描述节录自:“Manipulating the Smallest Building Blocks of Life to Defeat the World’s Biggest Infectious Disease Killer,” amFAR,The Foundation for AIDS Research press release (February 18,2010).
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