打字猴:1.7006495e+09
1700649500
1700649501 关于小鼠和人类之间基因表现的比较,详见:“Genomic responses in mouse models poorly mimic human inflammatory diseases,” Proceedings of the National Academy of Sciences of the United States of America 110(Feb 2013).
1700649502
1700649503 人源化小鼠的HIV感染模型文献回顾,详见:“Humanized mouse models of HIV infection,” AIDS Reviews 13(3):135-148(2011).
1700649504
1700649505 部分研究者并不相信人源化小鼠可提供任何有价值的治疗模型。该意见详见:“The mouse is out of the bag:insights and perspectives on HIV-1-infected humanized mouse models,” Experimental Biology and Medicine 236(2011).
1700649506
1700649507 朱恩在以毒攻毒的人源化小鼠上给予锌指核酸酶的试验结果,详见:“Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases,” Nature Biotechnology 26(2008).
1700649508
1700649509 朱恩在HIV阳性志愿者中进行的CCR5 ZFN临床试验的结果,发表于:“HAART treatment interruption following adoptive transfer of zinc finger nuclease(ZFN)modified autologous CD4+ T-cells(SB-728-T)to HIV-infected subjects demonstrates durable engraftment and suppression of viral load,” Abstract #165,18th Conference on Retroviruses and Opportunistic Infections,Boston,MA(2011);“Induction of acquired CCR5 deficiency with zinc finger nuclease-modified autologous CD4 T cells(SB-728-T)correlates with increases in CD4 count and effects on viral load in HIV-infected subjects,” Abstract #155,19th Conference on Retroviruses and Opportunistic Infections,Seattle,WA(2012).
1700649510
1700649511 2011年,米利曼医学指数评估了朱恩团队在自体移植上,给予CCR5锌指核酸的花费,为363800美元。因此这也使得自体移植的花费,较终身抗病毒疗程的花费节省了将近30万美元。详见:http://publications. milliman.com/research/health-rr/pdfs/2011-us-organ-tissue. pdf.
1700649512
1700649513 26 有个孩子被治愈了,那又如何
1700649514
1700649515 一名染上HIV的儿童被治愈的报道,详见:“Functional HIV cure after very early ART of an infected infant,” Abstract #48LB,20th Conference on Retroviruses and Opportunistic Infections,Atlanta,GA(2013).
1700649516
1700649517 关于布卢和瓦格纳的谈话内容,详见:“Revolutionary treatment begins,” University of Minnestota News (April 24,2013).
1700649518
1700649519 布朗打给布卢的电话内容,详见:“Babies could be key to HIV cure,” Washington Blade (Aplril 26,2013).
1700649520
1700649521 关于马戈利斯的背景信息,引述自个人访谈。
1700649522
1700649523 关于组蛋白去乙酰酶抑制剂(HDACi)在癌症治疗上的历史,与伏立诺他作为第一种由FDA核准的药剂等,详见:“Histone deacetylase(HDAC)inhibitors in recent clinical trials for cancer therapy,” Clinical Epigenetics 1(Dec 2010).
1700649524
1700649525 马戈利斯对HDACi的一种——丙戊酸进行的调查,详见:“Coaxing HIV-1 from resting CD4 T cells:histone deacetylase inhibition allows latent viral expression,” AIDS 18(May 21,2004),and “Depletion of latent HIV-1 infection in vivo:a proof-of-concept study,” Lancet 366(Aug 13,2005).
1700649526
1700649527 马戈利斯测试伏立诺他的数据,详见:“Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid,” AIDS Research and Human Retroviruses 25(Feb 2009).
1700649528
1700649529 马戈利斯撰写了一篇关于HDACi的精彩文献回顾,详见:“Histone deacetylase inhibitors HIV latency,” Current Opinion in HIV and AIDS 6(2011).
1700649530
1700649531 马戈利斯为大众所做的演讲内容,详见:“Administration of vorinostat disrupts HIV-1 latency in patients on ART,” Abstract #157LB,19th Conference on Retroviruses and Opportunistic Infections,Seattle,WA(2012).
1700649532
1700649533 莱温将其对伏立诺他的试验数据与分析结果,分享于:“HIV latency and eradication:clinical perspectives,” Abstract #106,19th Conference on Retroviruses and Opportunistic Infections,Seattle,WA(2012).
1700649534
1700649535 “这是有史以来,我们首度证明有方法可以专门针对潜伏病毒,这是迈向治愈HIV感染的第一步。”此话引述自莱温,收录于:“Drug helps purge hidden HIV virus,UNC study shows” from the University of North Carolina School of Medicine(March 8,2012).
1700649536
1700649537 27 锌指一弹
1700649538
1700649539 以我学位论文的研究结果为基础,坎农与我合著了一篇论文:“Zinc finger nuclease-mediated CCR5 knockout hematopoietic stem cell transplantation controls HIV-1 in vivo,” Nature Biotechnology 28(Aug 2010).
1700649540
1700649541 坎农的背景信息,援引自个人访谈。
1700649542
1700649543 加州再生医学研究所为“梦之队”提供了资助,此事详见:http://www.cirm.ca.gov/our-funding/awards/ziinc-finger-nuclease-based-stem-cell-therapy-aids.
1700649544
1700649545 坎农所说的“这方法能奏效,就像是‘根本理所当然嘛’!这是最稀松平常的事情。我那时还没心理准备,看到其他人对这些结果叹为观止”。摘录自:“Locking Out HIV,” CIRM Annual Report (2011).
1700649546
1700649547 关于亨里奇与库里茨克斯的背景信息,援引自个人访谈。
1700649548
1700649549 亨里奇第一篇关于波士顿病人的结果,详见:“Long-term reduction in peripheral blood HIV-1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation in two HIV-positive individuals,” Abstract THAA0101,XIX International AIDS Conference,Washington,DC(2012).
[ 上一页 ]  [ :1.7006495e+09 ]  [ 下一页 ]