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关于服用地达诺新(DDI)的困难,有一篇令人捧腹的文章:Queer and Loathing:Rants and Raves of a Raging AIDS Clone by David B. Feinberg(Penguin Books,1995).
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关于地达诺新的生物利用度,可参见百时美施贵宝公司的包装说明中的表10。
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16 家人和陌生人的慰藉
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关于家人的支持对于女、男同性恋者以及双性恋者的健康产生正面影响的研究,包括:“The health of people classified as lesbian,gay and bisexual attending family practitioners in London:a controlled study,” BMC Public Health 6(2006);“Family rejection as a predictor of negative health outcomes in white and Latino lesbian,gay,and bisexual young adults,” Pediatrics 123(2009);“Parents’ supportive reactions to sexual orientation disclosure associated with better health:results from a population-based survey of LGB adults in Massachusetts,” Journal of Homosexuality 59(2012);“A qualitative exploration of sexual risk and HIV testing behaviors among men who have sex with men in Beirut,Lebanon,” PLoS ONE 7(2012).
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关于HIV与恶病质的讨论,详见:“HIV-related cachexia:potential mechanisms and treatment,” Oncology 49(1992).
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关于线粒体、抗逆转录病毒疗法与脂肪萎缩的关联,详见:“Mitochondrial RNA and DNA alterations in HIV lipoatrophy are linked to antiretroviral therapy and not to HIV infection,” Antiviral Therapy 13(2008).
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17 抓住时机
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所有引述与利西耶维兹博士的相关背景信息,皆来自个人访谈。
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关于信使RNA如何进行转译,详见:The Cell:A Molecular Approach ,2nd edition,by Geoffrey Cooper(Sinauer Associates,2000).
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由利西耶维兹开创的基因疗法,可详见她的论文:“Gene therapy approaches to HIV infection,” American Journal of Pharmacogenomics 2(2002).
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关于利西耶维兹与洛里的研究机构的更多信息,详见RIGHT网站:http://www.rightinstitute.net.
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18 移植手术
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一篇关于哪位AML患者应当进行骨髓干细胞移植,以及原因为何的回顾:“Who should be transplanted for AML?” Leukemia 15(2001).
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关于AML患者在二次移植后的低存活率数据,详见:“Prognosis of patients with a second relapse of acute myeloid leukemia,” Leukemia 14(2000). 关于AML复发的成年人患者的5年存活率仅有11%,详见:“Prognostic index for adult patients with acute myeloid leukemia in first relapse,” American Society of Clinical Oncology 23(2005).
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关于调理疗程如何抑制AML移植患者的免疫系统,详见:“Myeloablative conditioning regimens for AML allografts:30 years later,” Bone Marrow Transplantation 32(2003).
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19 “我们可能已经消灭HIV”
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关于临床医师如何应用的比例,详见:“CD4 percentage,CD4 number,and CD4:CD8 ratio in HIV infection:which to choose and how to use,” Journal of Acquired Immune Deficiency Syndromes 2(1989).
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西里西亚诺极具影响力的论文:“Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy,” Science 278(1997).
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关于血液中静止T细胞所占的比例及其与HIV的关联,详见:“Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells,” Nature 435(2005).
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关于淋巴结为HIV最适切的目标,详见:“Lymph node pathology of acquired immunodeficiency syndrome(AIDS),” Annals of Clinical and Laboratory Science 20(1990).
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福克斯的论文使他参与了两位柏林病人的治疗:“HIV in infected lymph nodes,” Nature 370(1994).
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关于淋巴结结构的破坏,详见:“Human immunodeficiency virus pathogenesis:insights from studies of lymphoid cells and tissues,” Clinical Infectious Disease 33(2001).
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自1996年起,沃克发表了数篇具影响力的论文,包括:“Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor,” Journal of Infectious Diseases 173(1996);“T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones:analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant,” Journal of Experimental Medicine 183(1996);“Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection,” AIDS Research and Human Retroviruses 12(1996);“Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load,” Journal of Immunology 156(1996);“Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes,” Journal of Virology 70(1996).
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关于HIV和干扰素-γ在ELISPOT中的交互作用,详见:“The role of IFN-[gamma] Elispot assay in HIV vaccine research,” Nature 4(2009).
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关于在HIV中使用ELISPOT的问题的争论,详见:“The role of IFN- Elispot assay in HIV research,” Nature Protocols 4(2009).
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