打字猴:1.70064948e+09
1700649480
1700649481 关于骨髓移植与冷战的信息,引自:“Atomic Medicine:the Cold War Origins of Origins of Biological Research,” History Today 59(2009).
1700649482
1700649483 所有关于莱文的背景信息,援引自个人访谈。
1700649484
1700649485 朱恩和莱文合著了一篇文章,讲述其CCR5基因疗法的操作方法:“Blocking HIV’s attack,” Scientific American 306(2012).
1700649486
1700649487 莱文和朱恩注意到的一篇关于树突状细胞的论文:“Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 co-stimulation,” Science 272(1996).
1700649488
1700649489 关于兰菲尔的背景信息,援引自个人访谈。
1700649490
1700649491 关于锌指核酸酶(ZFN)的开发与应用,可进一步参见:“Zinc finger nucleases:custom-designed molecular scissors for genome engineering of plant and mammalian cells,” Nucleic Acids Research 33(2005).
1700649492
1700649493 关于SIV、HIV,可进一步参见:“Where the wild things are:pathogenesis of SIV infection in African nonhuman primate hosts” HIV\AIDS Reports 7(2010)以及“Natural SIV hosts:showing AIDS the door,” Science 335(2012).
1700649494
1700649495 关于SIV已经演化超过32000年的证据,详见:“Islander biogeography reveals the deep history of SIV,” Science 329(2010).
1700649496
1700649497 关于SIV感染,发病猴与不发病猴的模型比较,详见:“AIDS pathogenesis:a tale of two monkeys,” Journal of Medical Primatology 37(2008).
1700649498
1700649499 关于人类与黑鼠B6之间基因型的相似度,详见:“Of Mice and Men:Striking Similarities at the DNA Level Could Aid Research,” San Francisco Chronicle (December 5,2002).
1700649500
1700649501 关于小鼠和人类之间基因表现的比较,详见:“Genomic responses in mouse models poorly mimic human inflammatory diseases,” Proceedings of the National Academy of Sciences of the United States of America 110(Feb 2013).
1700649502
1700649503 人源化小鼠的HIV感染模型文献回顾,详见:“Humanized mouse models of HIV infection,” AIDS Reviews 13(3):135-148(2011).
1700649504
1700649505 部分研究者并不相信人源化小鼠可提供任何有价值的治疗模型。该意见详见:“The mouse is out of the bag:insights and perspectives on HIV-1-infected humanized mouse models,” Experimental Biology and Medicine 236(2011).
1700649506
1700649507 朱恩在以毒攻毒的人源化小鼠上给予锌指核酸酶的试验结果,详见:“Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases,” Nature Biotechnology 26(2008).
1700649508
1700649509 朱恩在HIV阳性志愿者中进行的CCR5 ZFN临床试验的结果,发表于:“HAART treatment interruption following adoptive transfer of zinc finger nuclease(ZFN)modified autologous CD4+ T-cells(SB-728-T)to HIV-infected subjects demonstrates durable engraftment and suppression of viral load,” Abstract #165,18th Conference on Retroviruses and Opportunistic Infections,Boston,MA(2011);“Induction of acquired CCR5 deficiency with zinc finger nuclease-modified autologous CD4 T cells(SB-728-T)correlates with increases in CD4 count and effects on viral load in HIV-infected subjects,” Abstract #155,19th Conference on Retroviruses and Opportunistic Infections,Seattle,WA(2012).
1700649510
1700649511 2011年,米利曼医学指数评估了朱恩团队在自体移植上,给予CCR5锌指核酸的花费,为363800美元。因此这也使得自体移植的花费,较终身抗病毒疗程的花费节省了将近30万美元。详见:http://publications. milliman.com/research/health-rr/pdfs/2011-us-organ-tissue. pdf.
1700649512
1700649513 26 有个孩子被治愈了,那又如何
1700649514
1700649515 一名染上HIV的儿童被治愈的报道,详见:“Functional HIV cure after very early ART of an infected infant,” Abstract #48LB,20th Conference on Retroviruses and Opportunistic Infections,Atlanta,GA(2013).
1700649516
1700649517 关于布卢和瓦格纳的谈话内容,详见:“Revolutionary treatment begins,” University of Minnestota News (April 24,2013).
1700649518
1700649519 布朗打给布卢的电话内容,详见:“Babies could be key to HIV cure,” Washington Blade (Aplril 26,2013).
1700649520
1700649521 关于马戈利斯的背景信息,引述自个人访谈。
1700649522
1700649523 关于组蛋白去乙酰酶抑制剂(HDACi)在癌症治疗上的历史,与伏立诺他作为第一种由FDA核准的药剂等,详见:“Histone deacetylase(HDAC)inhibitors in recent clinical trials for cancer therapy,” Clinical Epigenetics 1(Dec 2010).
1700649524
1700649525 马戈利斯对HDACi的一种——丙戊酸进行的调查,详见:“Coaxing HIV-1 from resting CD4 T cells:histone deacetylase inhibition allows latent viral expression,” AIDS 18(May 21,2004),and “Depletion of latent HIV-1 infection in vivo:a proof-of-concept study,” Lancet 366(Aug 13,2005).
1700649526
1700649527 马戈利斯测试伏立诺他的数据,详见:“Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid,” AIDS Research and Human Retroviruses 25(Feb 2009).
1700649528
1700649529 马戈利斯撰写了一篇关于HDACi的精彩文献回顾,详见:“Histone deacetylase inhibitors HIV latency,” Current Opinion in HIV and AIDS 6(2011).
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